As mentioned in previous posts, Adaptive Laboratory Evolution was used to generate superior strains of Actinobacillus succinogenes and Basfia succiniproducens in terms of tolerance to high sugar concentration. In the past months, we isolated over 80 evolved ALE strains. Now, the screening of the [...]
Last week IVEM, together with DTU and AUTH, operated the 6th batch in the industrial unit, paying attention to every detail and analysing all aspects of the process and the unit. Our colleagues, Antonio from DTU and Antonios from AUTH, travelled to Spain for the whole week in order [...]
Progress is ongoing regarding project’s Deliverables (D3.3 Downstream processing: strategy, technology, cost analysis, D4.3 Best operating conditions for improvement the lab scale system, D4.4 Report on the robustness of the process control). AUTH planned with DTU and IVEM to visit the WWTP [...]
In the last weeks, NORVENTO together with IVEM, AINIA and BIOTEHCPRO have been working on one of the last deliverables of the project, the Business Plan. In this deliverable, an in-depth analysis of the target market is being carried out. This includes the capital investment and analysis of the [...]
After running Adaptive Laboratory Evolution experiments to improve the tolerance of Actinobacillus succinogenes and Basfia succiniproducens to high concentrations of sugars, newly isolated evolved strains were tested for their improved substrate tolerance. The screening of new evolved isolates from [...]
Temperature graphic from a previous batch NEOSUCCESS starts the year preparing its next batch (P5), for which they will make some minor adjustments in the sterilisation step in order to guarantee the success of our selected strain’s growth and fine-tune the process. Some of these adjustments are [...]
NEOSUCCESS partners still work on optimizing the fermentation train. To this end, AINIA continues providing the inoculum that will be transferred into the WWTP plant in Paterna. Every step has its own peculiarities, so all our effort is put into reaching the quality standard that the medium and the [...]
Almost at the end of 2022, the work progress performed throughout the year is being evaluated and an effort is made to plan the next steps. The goal is to fulfil every aspect of the project’s demands in the upcoming months. For the successful implementation of the work ahead, [...]
The week of November 14th, the NORVENTO team went to Valencia to operate the Down Stream Process (DSP) unit of the Neosuccess project. The DSP purifies the succinic acid obtained in the Up Stream Process (USP) by removing residual sugars and other unwanted components. During the visit, the NORVENTO [...]
The Adaptative Laboratory Evolution (ALE) experiments for improving the fitness of Actinobacillus succinogenes and Basfia succiniciproducens were successfully completed. This procedure generated multiple mixed populations of evolved strains derived from two wild-type strains, which led to the [...]
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