Figure 1. Workflow for isolation and validation of evolved succinic-acid-producing strains. DTU is currently preparing the pipeline for genomic profiling of the mutant ALE (Adaptive laboratory Evolution) strains with superior tolerance to high substrate concentrations. A second ALE protocol to [...]
The Adaptative Laboratory Evolution (ALE) experiments for improving the fitness of Actinobacillus succinogenes and Basfia succiniciproducens were successfully completed. This procedure generated multiple mixed populations of evolved strains derived from two wild-type strains, which led to the [...]
After the preliminary experiments, DTU completed a series of Adaptation Laboratory Evolution (ALE) experiments to improve the robustness of the strains Actinobacillus succinogenes 130Z and Basfia succiniciproducens. The ALE procedure significantly improved the tolerance of the evolved strains to [...]
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