Figure 1. Workflow for isolation and validation of evolved succinic-acid-producing strains. DTU is currently preparing the pipeline for genomic profiling of the mutant ALE (Adaptive laboratory Evolution) strains with superior tolerance to high substrate concentrations. A second ALE protocol to [...]
As mentioned in previous posts, Adaptive Laboratory Evolution was used to generate superior strains of Actinobacillus succinogenes and Basfia succiniproducens in terms of tolerance to high sugar concentration. In the past months, we isolated over 80 evolved ALE strains. Now, the screening of the [...]
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